Zai Lab has a broad and validated late-stage pipeline in oncology and infectious disease. We currently have 2 products commercialized and 4 drugs approved in the U.S. (marked with * below). Overall, our pipeline consists of over 15 drug candidates with over 20 ongoing or planned clinical trials.
Oncology
Molecule Name
Potential Indication
Phase
Pre-clinical
Phase I
Phase II / POC
Phase III / Pivotal
NDA Filed
Marketed
Ovarian Cancer (2nd line maintenance) *
Mainland China, HK & Macau (China)
Ovarian Cancer (1st line maintenance)*
Mainland China
Ovarian Cancer (late line treatment)*
Gastric Cancer (I/O[3] combo)[1]
Other solid tumors[2] (I/O[3] combo)
Glioblastoma (GBM) *
Hong Kong (China), mainland China
Mesothelioma* (Optune Lua)
Brain Metastases from NSCLC
B-NHL - r/r FL, r/r DLBCL, r/r MCL, r/r MZL, etc. [6, 7]
ROS1+ NSCLC[4], NTRK+[8] solid tumors
HER2+ Gastric/GEJ Cancer[9] (combo[10])
Hepatocellular carcinoma (HCC) (combo with brivanib)
Oncology and autoimmune disease
Generalized Myasthenia Gravis
Immune Thrombocytopenic Purpura
Oncology and autoimmune disease
ROS1+ NSCLC[4], NTRK+[8] solid tumors
B-NHL - r/r FL, r/r DLBCL, r/r MCL, r/r MZL, etc. [6, 7]
Ovarian Cancer (2nd line maintenance) *
Ovarian Cancer (1st line maintenance)*
Ovarian Cancer (late line treatment)*
Gastric Cancer (I/O[3] combo)[1]
Other solid tumors[2] (I/O[3] combo)
Mesothelioma* (Optune Lua)
Brain Metastases from NSCLC
Hepatocellular carcinoma (HCC) (combo with brivanib)
HER2+ Gastric/GEJ Cancer[9] (combo[10])
Hepatocellular Carcinoma (HCC) [2]
Acute Bacterial Skin and Skin Structure Infection (ABSSSI) *
Community-Acquired Bacterial Pneumonia (CABP) *
A.Baumanii Bacterial Infections
Infectious Disease and Autoimmune
Molecule Name
Potential Indication
Phase
Pre-clinical
Phase I
Phase II / POC
Phase III / Pivotal
NDA Filed
Marketed
Acute Bacterial Skin and Skin Structure Infection (ABSSSI) *
Community-Acquired Bacterial Pneumonia (CABP) *
A.Baumanii Bacterial Infections
Generalized Myasthenia Gravis
Immune Thrombocytopenic Purpura
Generalized Myasthenia Gravis
Immune Thrombocytopenic Purpura
Oncology and autoimmune disease
ROS1+ NSCLC[4], NTRK+[8] solid tumors
B-NHL - r/r FL, r/r DLBCL, r/r MCL, r/r MZL, etc. [6, 7]
Ovarian Cancer (2nd line maintenance) *
Ovarian Cancer (1st line maintenance)*
Ovarian Cancer (late line treatment)*
Gastric Cancer (I/O[3] combo)[1]
Other solid tumors[2] (I/O[3] combo)
Mesothelioma* (Optune Lua)
Brain Metastases from NSCLC
Hepatocellular carcinoma (HCC) (combo with brivanib)
HER2+ Gastric/GEJ Cancer[9] (combo[10])
Hepatocellular Carcinoma (HCC) [2]
Acute Bacterial Skin and Skin Structure Infection (ABSSSI) *
Community-Acquired Bacterial Pneumonia (CABP) *
A.Baumanii Bacterial Infections